In the ever-evolving wellness world, few supplements have generated as much excitement as Nicotinamide Adenine Dinucleotide (NAD). This cellular powerhouse is quickly becoming a go-to for those looking to boost longevity, energy, and overall well-being.

NAD, a coenzyme found in every cell of the body, fuels almost every vital function that keeps us going.

What is NAD?

According to the National Institutes of Health, NAD is a coenzyme found in every cell of the body, playing a critical role in energy production, DNA repair, and regulating circadian rhythms (our body clock). In essence, NAD fuels almost every vital function that keeps us going. However, as we age, NAD levels naturally decline, contributing to issues like fatigue, poor skin health, and cognitive decline. Supplementing with NAD can help replenish these levels, supporting the body’s natural processes and promoting vitality.

Slowing Down Age & Increasing Longevity

NAD has gained attention for its potential to slow aging. It activates sirtuins—proteins that regulate inflammation, stress resistance, and longevity, with SIRT1 often called the “longevity gene.” Boosting NAD can enhance sirtuin activity, potentially extending the lifespan of cells. Early studies suggest that maintaining NAD levels may protect against age-related diseases such as Alzheimer’s and cardiovascular conditions, positioning NAD as a promising ally in the quest for longevity.

Replenishing Energy Levels

Low energy affects every aspect of life, from brain fog to sluggishness. NAD, crucial for cellular energy production, helps combat this by replenishing depleted reserves. Unlike caffeine, NAD works to restore the body's natural energy cycle, keeping you alert and energized throughout the day. Whether you're a busy professional, a parent, or an active individual, NAD supplementation offers sustained vitality to meet life’s demands.

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Cognitive Function and Mental Clarity

As we navigate busier lives, cognitive function becomes a top priority. NAD has neuroprotective properties that support mitochondrial function in brain cells, boosting mental clarity, focus, and memory. Studies also suggest NAD may help prevent cognitive decline and shield against neurodegenerative diseases, offering a solid reason to consider it for cognitive enhancement.

NAD and Skin Health

For youthful, glowing skin, it’s not just about topicals—NAD’s role in cellular repair is key. By promoting DNA repair and enhancing mitochondrial function, NAD supplementation can reduce wrinkles, fine lines, and other signs of aging caused by environmental stressors like sun damage. Whether you're in your 30s or 60s, NAD helps rejuvenate skin from the inside out, offering an internal boost to external beauty.

Should You Try NAD?

If you’re searching for a way to promote overall vitality, improve cognitive function, and support healthier aging, NAD may be a perfect addition to your wellness routine. From its role in cellular repair to its potential in boosting energy levels, NAD supplements could help rejuvenate your body and mind.

NAD+ is now a trending supplementation in wellness and longevity.

Recommended Dosage for NAD+ Supplementation

NAD+ supplementation can be administered through various methods, including intravenous (IV) infusions, subcutaneous (SQ) injections, and oral supplements. Here's a general guide:

Intravenous (IV) Infusion 

(also known as drip treatment)

• Dosage: Typically ranges from 500 mg to 1,000 mg per session.

• Frequency: Administered over several hours, often in a clinical setting.

• Note: Provides 100% bioavailability, allowing for maximum absorption.

NAD+ supplementation can be administered through IV drip treatments.

Subcutaneous (SQ) Injections 

(means the injection is given in the fatty tissue, just under the skin)

• Starting Dose: Begin with 50 mg (0.5 mL) once weekly for 4 weeks.

• Titration: If no/minimal side effects, increase to 100 mg (1 mL) once weekly.

• Maximum Dose: 100 mg once weekly.

• Administration Sites: Rotate between the abdomen, upper arm, and thigh to prevent irritation

Oral Supplements

• Forms: Nicotinamide Riboside (NR) or Nicotinamide Mononucleotide (NMN) are common precursors.

• Dosage: Typically ranges from 300 mg to 1,000 mg per day

As with any supplement or therapy, it’s important to consult with a healthcare professional before beginning any new regimen. Several clinics around Manila, such as Centro Holistico, are offering services to administer NAD subcutaneously, with most offering free consultations before the therapy.

How to Boost Your NAD Levels Naturally

Now that you know why NAD is a supplement worth considering, you might be wondering how to naturally increase your levels. While our bodies produce NAD, certain lifestyle changes can help support its production:

1. Exercise Regularly: Physical activity has been shown to increase NAD levels, especially endurance exercises like running and cycling. These activities promote mitochondrial health, leading to more energy and improved overall health.

2. Limit Sugar Intake: High sugar levels can deplete NAD in the body, so cutting back on sugary foods is a good idea for those looking to maintain their NAD levels.

3. Intermittent Fasting: Emerging research suggests that fasting can stimulate the production of NAD, as it forces the body to activate pathways involved in cellular repair and energy production.

4. Consider Supplementation: While lifestyle changes are crucial, NAD supplements—either in the form of Nicotinamide Riboside (NR) or Nicotinamide Mononucleotide (NMN)—are an excellent way to directly support your body’s NAD levels.

Healthy lifestyle changes can help support NAD production.

Sources of NAD in Nutrition

While NAD shots and supplements are popular for their quick and targeted impact, the good news is that your body can also produce NAD from certain foods. Incorporating these into your diet can help maintain healthy NAD levels naturally:

1. BEEF: Rich in niacin, beef is one of the best sources for supporting NAD production in your body. Opt for grass-fed beef for the highest nutritional value.

Your body can produce NAD naturally with the right diet and nutrition.

2. EGGS: Eggs, particularly the yolks, are another excellent source of niacin. They provide a variety of essential nutrients that support your overall health, including NAD production.

3. AVOCADOS: Avocados are packed with healthy fats and vitamins, including niacin. Their creamy texture and rich nutrient profile make them a must-have for those looking to boost their NAD levels naturally.

4. SALMON: Salmon, a powerhouse of omega-3 fatty acids, also contains niacin. It’s a perfect addition to your diet for both heart health and NAD support.

NAD is no longer just a supplement for the biohacking crowd; it’s becoming an essential component in our pursuit of holistic wellness. So, why not give your body the cellular support it deserves? Replenish your energy, protect your brain, and let your skin glow from the inside out—NAD might be exactly what you need. After all, we only have one body; might as well take care of it the best we can while reaping the benefits of today’s biotechnology.